An inherited disease in which the KIDNEYS contain many cysts. These grow in size until normal kidney tissue is largely destroyed. Cysts may also occur in other organs such as the liver. In adults, the disease will cause HYPERTENSION and kidney failure. There is also a juvenile form. Treatment is that of the high blood pressure and kidney failure and, in patients with advanced and progressive kidney problems, the drug tolvaptan (a selective VASOPRESSIN RECEPTOR antagonist) was approved for use in Europe, Canada and Japan in 2015 (see DIALYSIS and TRANSPLANTATION).