A suggestion by two epidemiologists, made in the British Medical Journal in 2003, that many lives could be saved if all persons aged over 55 took a daily combination pill they termed the polypill. Its components would be ASPIRIN, a CHOLESTEROL-lowering agent, FOLIC ACID and two blood-pressure-lowering agents. The suggestion caused a massive correspondence as it implied treating a whole population rather than individuals considered to be at special risk. The concept remains a matter of debate.