A group of ANTIDEPRESSANT DRUGS which inhibit the re-uptake of serotonin by brain cells. They are better tolerated and safer in overdose than other antidepressants. Examples are; FLUOXETINE fluvoxamine, PAROXETINE, sertraline and citalopram. There are various possible side-effects and some groups of patients who should not be treated with SSRIs. Particular caution must be exercised when prescribing for those under 18, in whom only paroxetine has been shown to be of any benefit and where there may be a small risk of these drugs provoking suicidal thoughts. (See also MENTAL ILLNESS.)