These stimulate the activity of the SYMPATHETIC NERVOUS SYSTEM. There are three groups: inotropic and vasoconstrictor sympathomimetics, and those used for cardiopulmonary resuscitation. The properties of these drugs vary according to whether they act on alpha or beta adrenergic receptors.
act on beta receptors in heart muscle (see HEART), increasing its contractility and sometimes the heart rate. DOBUTAMINE and DOPAMINE are cardiac stimulants, while dopexamine acts on heart muscle and, via peripheral dopamine receptors, increases the excretion of URINE.
These drugs temporarily raise the BLOOD PRESSURE by constricting peripheral blood vessels. Sometimes they are used as a speedy way of raising blood pressure when other treatment has failed. EPHEDRINE and methoxamine hydrochloride are examples of this type of sympathomimetic.
Epinephrine (ADRENALINE) is given intravenously in cardiac arrest. Other drugs used include ATROPINE and CALCIUM.