Also known as Buerger's disease, this is an inflammatory disease involving the blood vessels and nerves of the limbs, particularly the lower limbs. TOBACCO is an important cause. Pain is the outstanding symptom, accompanied by pallor of the affected part; intermittent CLAUDICATION caused by a reduction in blood supply is common. Sooner or later ulceration and GANGRENE tend to develop in the feet or hands when AMPUTATION of the affected part may be necessary. There is no specific treatment, but, if seen in the early stages, considerable relief may be given to the patient. Regular walking exercise is helpful and affected individuals must not smoke.