The eponym for hepatolenticular degeneration, a familial disease in which there is an increased accumulation of copper in the liver, brain, and other tissues including the kidneys. Its main manifestation is the development of tremor and rigidity, with difficulty in speech. In many cases there is improvement following treatment with dimercaprol, penicillamine, or trientine dihydrochloride, substances which provoke an increased excretion of copper.