Progressive thickening and contracture of the FASCIA in the palm of the hand with adherence of the overlying skin. A clawing deformity of the fingers, particularly the little and ring fingers, develops. Some patients also have liver disease, diabetes, epilepsy, and gout. Treatment may be unnecessary but surgery can help prevent fixed deformity. Research suggests that injection with collagenase may help in mild disease. Recurrence is not uncommon even after operation.