A group of ANTIBIOTICS including ERYTHROMYCIN, clarithromycin, azithromycin and spiramycin. They check PROTEIN synthesis in BACTERIA and are active against several bacterial species including gram-positive COCCI and rods; they are particularly useful for people with PENICILLIN allergy. Clarithromycin is potent against Helicobacter pylori and is useful in treating DYSPEPSIA, while azithromycin is effective against infections caused by Legionella spp. (see LEGIONNAIRE'S DISEASE) and GONOCOCCI. Spiramycin is a restricted-use macrolide prescribed for pregnant patients with TOXOPLASMOSIS.