(Depo-Provera®) A long-acting injectable PROGESTERONE (female sex hormone) preparation used for contraception; however, it should be given only after counselling and with full description of its action. In adolescents it might be recommended when other methods are inappropriate, and in all women the risks and benefits require reassessment. There are reasons for not prescribing it to women prone to OSTEOPOROSIS. The drug is also used as second- or third-line treatment for patients with endometrial cancer and in some cases of prostate cancer.